Endocrine Abstracts

Background: Impaired insulin and glucose levels are implicated in the etiology of cardiovascular disease, however, their influence on the formation and composition of atherosclerotic plaque remains unclear.Purpose: To investigate the association between fasting serum insulin and glucose levels with atherosclerotic plaque composition in the carotid artery.Methods: In 1740 participants (mean age 72.9 years, 46% women, 14.4% diabetes ...

Background: Small functional pituitary adenomas can cause severely disabling symptoms and early death, however, surgical planning is often complicated due to inconclusive diagnostic MRI in up to 40% of patients and therefore hamper cure rates. We here introduce a novel method for the detection of small functional pituitary adenoma by O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET) PET-MRI.Methods: Patients with Cushing’s disease (CD) or acromegaly wit...